An Epic 10 Day Road Trip Itinerary From Milan To Rome
Updated: Aug 30
Here's my guide to the perfect 10 day road trip from Milan to Rome, a popular tourist route. It's only a 6 hour drive from Milan to Rome. But this well-traveled route is dense with amazing must see medieval villages, ornate palazzos, Roman ruins, and sublime treasures of the Renaissance.
There's plenty of great destinations to explore along the way. This super detailed itinerary is perfectly adjustable. You can make it shorter or longer, depending on your available vacation time or personal fast/slow pace. I've tried to give you a balance of cities and leisurely villages, with day trip options as well.
You start with Italy's exciting northern capital of Milan and end in Italy's ancient southern capital of Rome. Along the way, you'll visit some of Italy's most beautiful towns in northern Italy, Cinque Terre, and Tuscany. You may have a near overdose art high on this trip -- with ancient Roman ruins, iconic masterpieces, and world class museums at every turn.
This itinerary takes you to all of the must see sites, historic landmarks, and must visit museums. It tells you everything you need to see, do, and eat on this Milan to Rome road trip.
Recommended 10 Day Itinerary for a Road Trip from Milan to Rome
Here's where I recommend you stop and explore on your road trip from Milan to Rome.
Day 1: Explore Milan
Day 2: Pick up car, stop in Parma, overnight in Bologna
Day 3: Explore Bologna
Day 4: Drive To Lucca and explore, overnight in Lucca
Day 5: Day Trip To Cinque Terre or Pisa from Lucca
Day 6: Drive To Florence and explore
Day 7: Explore Florence
Day 8: Drive To Siena and explore, overnight in Rome
Day 9: Explore Rome
Day 10: Explore Rome
In this 10 day Milan to Rome travel itinerary, you'll have three bases: Milan (1 night), Bologna (2 nights), Lucca (2 nights), Florence (2 nights), and Rome (3 nights).
Day 1: Explore Milan
Milan is an amazing destination in northern Italy. It's a sleek and chic modern city, the thriving finance and fashion capital of Italy. Milan has a serious arts scene, breathtaking sites, and gastronomical delights.
Milan is not "an industrial city," as the uninitiated claim. Milan has personality, combining old world charm and "bright lights, big city" flair in compelling fashion. You can't help but be dazzled by Milan's architecture, historic sites, iconic art, and fantastic foodie scene.
You might be surprised to know that Milan has some of the greatest artistic treasures of the Renaissance. Milan's defining artistic moment was the arrival of Leonardo da Vinci in 1481. Hired by the Duke of Milan as a court artist, Leonardo produced some of his most important works in Milan, including his iconic The Last Supper, Milan's top attraction.
Aside from da Vinci, Milan is most well known for its massive Gothic Duomo, Sforza Castle, and its world class museums, including the Pinacoteca de Brera.
Milan Cathedral is a world renowned edifice. Built over 600 years beginning in 1368, the Duomo is a flamboyant Gothic masterpiece with 135 marble spires. It's the fourth largest church in the Europe, second in size in Italy only to St. Peter's Basilica in Rome.
The Pinacoteca is one of Europe's best (and most underrated) museums. Its exquisite collection is housed inside the beautiful late 17th century Palazzo Brera near the Duomo. The museum boasts works from the 14th to 20th centuries, including important pieces by artists such as Raphael, Caravaggio, Guercino, Bellini, Hayez, and Titian.
You can tour Milan's must see sites in one day. But you'll need to be efficient and tightly planned. I won't repeat myself. Here's my 24 hour step by step itinerary to make the most of your one day in Milan with tips on what to see/eat/do. Click here for a complete guide to Leonardo's The Last Supper and how to see this Renaissance masterpiece.
Day 2: Drive to Bologna, Visit Parma En Route
If you want to spend another day in Milan, just skip Parma and overnight in Milan. If you want to head to one of Italy's classic villages, stop in the lovely and underrated town of Parma, 2 hours from Milan. It's one hour+ further from Parma to Bologna, your next destination.
Parma is a UNESCO City of Gastronomy. Plan on lunch at Carne-Copia or F.I.S.H. Restaurant. Though known for its fine cuisine, Parma also satisfies appetites for art, music, and history. It was home to the artist Correggio, the opera composer Giuseppe Verdi, and the conductor Toscanini.
Parma is a sweet and colorful city. It has a pink Baptistery, precious Correggio frescos, and art-filled palaces. The entire town is dotted with red and yellow walls. Purple flowers cover the Ponte Verdi.
Parma is the place to take a Correggio course. You can find beautiful Correggio frescos in the cupola of Parma's Duomo, in the interior dome of San Giovani Evangelista Church, and in the Camera di San Paolo in the Benedictine monastery of St. Paul.
The Palazzo della Pilotta complex is also a must do in Parma. It's a former palace that houses museums dedicated to art and archaeology.
You enter via the Teatro Farnese, a beautiful wooden theater that will leave you gawking. The High Renaissance art works in the Galleria Nazionale will have the same effect. You'll find a rare Leonardo da Vinci, Canaletto cityscapes of Venice, and more Correggios.
Before leaving, have an aperitif at T Time, which overlooks the octagonal medieval baptistery. Then grab an early dinner at Borgo20, before hitting the road to Bologna to overnight there. It's a 1:15 drive to Bologna.
Day 3: Explore Bologna
Nicknamed La Grassa, or the Big Fat, for its delicious food, Bologna just oozes medieval charm. Bologna is a bit of a hidden gem in Italy. But it shouldn't be.
Bologna is a historic city filled with striking architecture, stony piazzas, a swathe of palaces and towers, and gourmet restaurants. Bologna specializes in tortellini, tagliatelle, ragù, cured hams, and mortadella. Don't start a diet here!
Bologna's must see sites are mostly situated in the city's main square, the massive Piazza Maggiore. You'll be greeted by a huge statue of a virile Neptune atop a fountain. It was created by one of the great late Renaissance sculptors, Giambologna, who was second only to Michelangelo in skill.
On one end of the piazza is the massive Basilica of San Petronio, honoring Bologna's patron saint. The basilica terrace offers a stunning view of Bologna's major monuments. On the other end of the piazza is the swishy Palazzo dei Rei Enzo. Just south of the square is the elegant Piazza Galvani and some of Bologna's finest porticos around Via Farini.
Have lunch at Ristorante da Nello al Montegrappa, just off the Piazza Maggiore. Or try out Bologna's new hotspot for pizza, Ranzani 13.
Then, head to Bologna's most famous site and most beautiful church, the grand Gothic Santo Stefano Church. It's a complex of seven churches, founded by Petronio atop a Roman temple. Legend holds that, when Dante was expelled from Florence for his politics, he wiled away time in the Romanesque cloisters.
Then head to Bologna's old medieval neighborhood, the Quadrilatero. Meander through the medieval lanes filled with deli shops and food markets.
Move on to the Piazza di Porta Ravegnana where Bologna's Le Due Torri, or two leaning towers, presides. You can climb 500 steps of the Asinelli Tower for panoramic views. Have a gelato or meal in the pretty piazza.
Be sure to walk under Bologna's famous 666 Portico at some point while you're in the city. It's the world's longest terra cotta arcade, stretching over 2.5 (sometimes arduous) miles from the Bonaccorsi Arch to the 17th century Sanctuary of the Madonna of San Luca. You'll have spectacular views from the sanctuary.
For dinner, click here for a fantastic guide to eating like a local in Bologna.
Day 4: Explore Lucca
The next morning, drive to Lucca. You'll need to park your car at a paid car park outside the city walls.
Beautifully preserved Lucca is still entirely contained within its stout Renaissance walls, designed by Leonardo da Vinci. Happily, Lucca never tore them down, like many Italian towns did to make way for modernity. Now, the walls are like a circular park for pedestrians and bikers. Walking the entire wall takes about 1 hour.
Lucca doesn't really have any must see sites, which means it's under the radar for most tourists. Lucca's appeal lies in its relaxed old world charm. It's best to stroll along the pretty cobbled streets and piazzas. Romanesque churches are around every corner.
The main pedestrian drag is Via Fillungo. Lucca's central square, Piazza Anfiteatro, was build around an ancient Roman arena. There's no remnants of the arena. But the handsome oval curve -- ringed with yellow medieval buildings -- still sits pretty. Take a break for lunch at Lucca's best pizza joint, Da Felice, in the historic center.
In Piazza San Michele, you'll find the lovely Church of San Michele, with a steep white marble Romanesque facade. In Piazza San Martino, you'll find the ancient Cathedral of San Martino, with a fetching brick and marble facade.
The cathedral was built to house one of Christendome's most famous relics, the Volto Santo. It was reputedly carved by Nicodemus, the man who helped depose Christ from the cross. The relic is kept in the freestanding Tempietto. Climb up the belfry for views of Lucca.
In its heyday, Lucca had over 100 towers, reminding me of Regensburg Germany. They were the homes of wealthy merchants families. The tallest surviving tower, the 14th century Torre delle Ore, is fetchingly capped with a bushy forest. You can climb this tower too.
End your day with dinner at Ristorante Gatta Ci Cova or Ristorante Giglio.
Day 5: Day Trip to Cinque Terre or Pisa From Lucca
On day 5, choose between a day trip to the Cinque Terre or to Pisa, depending on what interests you most. The Cinque Terre is an iconic destination on the Italian Riviera of spectacular natural beauty and endless views. But it takes some effort and logistics to visit and can be extremely over-touristed in high season.
Pisa is a less hassle good alternative for culture vultures. Pisa will also be crowded in high season with visitors coming to "hold up" the Leaning Tower. But Pisa's UNESCO-listed Field of Miracles is a magnificent assemblage of art and architecture. Pisa itself is also a charming town.
1. Cinque Terre Day Trip
The Cinque Terre is a series of 5 Italian villages set in craggy cliffs. They are Riomaggiore, Vernazza, Manarola, Monterosso, and Corniglia. You'll have dramatic views of sugar cube cottages, olive groves, terraced vineyards, and the Mediterranean Sea.
Cinque Terre is very doable as a day trip from Lucca. If you take your car, drive to La Spezia. Park at one of the many lots, and take the train (7 minutes) to Riomaggiore from there. Alternatively, drive to the first town, Riomaggiore, and park in the small lot there (likely full in the summer).
To get around the villages, either hike along goat paths (best option), hop on the milk train, or take a ferry ride. Check to make sure the hiking trails are open.
Start at Riomaggiore. Wander the charming lanes and climb the Catello di Riomaggiore. Grab a quick bite to eat at Bakery Rosi Roberta di Baudinelli. Then head to Vernazza.
Vernazza is widely considered the most postcard-perfect town in Cinque Terre. For the most spectacular views of your day, climb Castello Doria. Hang out in Piazza Marconi, with a sea of cafes. Before hitting the next village, grab a gelato at Gelateria Vernazza.
Then head to Monterosso, the largest of the Cinque Terre towns. Explore the quaint medieval old town behind the harbor. Pop into the Church of San Giovanni Battista.
That's probably all you'll have time for in one day. I'd head back to Lucca for dinner, since the food will be superior to the Cinque Terre.
2. Pisa Day Trip
Historic Pisa is only 30 minutes from Lucca. Most travelers in Tuscany descend in droves on tiny Pisa. They come for Pisa’s famously Leaning Tower on the spectacular UNESCO-listed Field of Miracles.
I think the tower is incredibly overrated. It leans because it’s a product of poor engineering and soft soil, nothing else. But you can take the requisite cheesy selfie with it. If you want, climb the spiral staircase for magnificent views. But you have to book in advance to ensure a spot.
The real gem of the Field of Miracles is Pisa’s exuberant Duomo. It’s the most ancient cathedral in Italy, older than the cathedral complexes in Siena and Florence. This Romanesque edifice was founded in 1118. The exterior is decorated with alternating black and white stripes.
Inside, there’s a central nave and two flanking aisles on each side, with intricate Corinthian columns and arches. In the apse, you’ll find mosaics attributed (perhaps erroneously) to the greatest 13th century Italian artist, Cimabue. There’s also an elaborate 14th century pulpit carved by Giovani Pisano and works by Ghirlandaio and Giambologna.
READ: Must See Sites in Pisa
The other great monument in Pisa is the circular monument in front of the Duomo, the Baptistery. Begun in 1153, there's still a full immersion baptismal font inside.
From the Women's Gallery above, you have views of the font. There's also a beautifully carved pulpit, created by Giovani's father Nicolo Pisano. It's considered one of the first works of Renaissance art.
The dome covering the Baptistery is actually two domes, which produces an odd acoustical effect. For a tip, the guards will sing and you can hear the melodic reverberations. Like the Leaning Tower, the Baptistery is on unstable soil and leans slightly toward the Duomo.
When you're done on the stunning Field of Miracles, visit the historic town itself, strolling along the Arno River. There are museums, palazzos, and piazzas to check out. If you want to stay in Pisa for dinner, try Spaghetteria Alle Bandierine or Osteria di Culegna.
You can either overnight in Lucca again, which my itinerary contemplates. Or, you can push on to Florence and spend 3 nights in Florence instead of 2 nights. It's a 1:10 drive from Pisa to Florence.
Day 6: Explore Florence
On Day 6 and 7 of your Italy trip, you'll explore my favorite city in Italy, Florence. Florence is an overwhelmingly beautiful city, the "Cradle of the Renaissance." With the best Medieval and Renaissance art in Europe, Florence is a veritable art lovers paradise.
Florence's entire historic center is a designated UNESCO World Heritage site. You'll need to buy your tickets for major attractions and must see sites well in advance.
1. Florence Cathedral Complex
To kick off day 6, head to the historic complex of Florence Cathedral, Santa Maria del Fiore, nicknamed the Duomo. I recommend purchasing a 72 hour combination pass that allows you to see all sites within the Duomo complex -- the Duomo, the Baptistry, the Giotto Bell Tower, and the Duomo Museum. They're all eminently worth seeing.
You should start with the stunning Duomo Museum to get the historical backdrop for all these structures. The museum is housed in the Piazza del Duomo at the back of Giotto's Bell Tower, behind the Duomo apse. The museum space is a fabulous treasure box of sculpture. Its rooftop terrace also offers a mesmerizing view of Brunelleschi's dome.
Then, head to Florence Cathedral -- the most prominent, and popular, landmark in Florence. It was built over 172 years, beginning in 1296. Florence Cathedral is made of brown sandstone and beautifully faced or "frosted" with pink, green, and white marble.
Filippo Brunelleschi's magnificent terra cotta colored dome, built from 1420-36, is the highlight. The burnt orange cupola is the very symbol of Florence. It’s decorated with frescos by Giorgio Vasari, a Florentine artist and the world’s first art historian. For panoramic views, climb up the cupola.
Next, stroll to the Baptistery, in front of the main facade of the Duomo. Dating from 1059, it's over a thousand years old. The Baptistery sports three magnificent sets of bronze doors. designed by Lorenzo Ghiberti and Nicola Pisano. Inside, is a stunning golden Byzantine style ceiling mosaic telling the story of the Last Judgement.
Break for lunch and a wander, enjoying the joys of a traffic free Florence. Try Casa del Vino, where you can get sandwiches, crostini, or charcuterie plates with a delicious glass of wine. All'Antico Vinaio is also a must try, just minutes away from Piazza della Signoria.
2. Ponte Vecchio
Then, take the classic stroll across Florence's storybook bridge, the Ponte Vecchio. It looks like cobbled together houses suspended over the Arno River. The bridge has three arches topped with a jumble of charming shops. Nowadays, you can buy expensive jewelry on the Ponte Vecchio.
3. Uffizi Gallery
In the afternoon, head to the Uffizi Gallery, Florence's #1 sight. It houses the world's best and most abundant collection of Italian Medieval and Renaissance art. The museum is a crowd pleaser, the third most visited site in Italy. The Uffizi deserves its accolades.
The Uffizi boasts seminal works from the 13th to 18th centuries. Here's where you'll find one of the world's most iconic paintings, Sandro Botticelli's Birth of Venus. If your time is limited, you should focus your efforts. The must see halls include the Hall 2 (Giotto), Hall 8 (Lippi), Halls 10-14 (Botticelli), Hall 15 (Leonardo), Hall 41 (Raphael and Michelangelo), Hall 83 (Titian), and Hall 90 (Caravaggio).
4. San Miniato al Monte
Finally, head to one of Florence's iconic viewpoints. Piazzale Michelangelo is the classic lookout point.
But if you hike 10 minutes further uphill, you'll come to the Basilica of San Miniato al Monte, Florence's crowning glory. The ancient church is a unique and harmonious blend of medieval architectural styles, pre-dating Florence's Renaissance treasures. Behind the church is a monumental cemetery with beautiful funerary art and sculptures.
Day 7: Explore Florence
1. Michelangelo's David
Start you morning bright and early at the Accademia Gallery. After the Uffizi, the Accademia is Florence's most visited museum. People flock in to see what is probably the world's most famous sculpture, Michelangelo's commanding statue of David.
The 17 foot sculpture is considered the embodiment of male beauty, a Calvin Klein-like model of physical perfection. David was commissioned for a niche of the Duomo. But it was considered too beautiful for that location. It's essential to have a reservation for the Accademia.
Heres my guide to Michelangelo's David and how to skip the line to see it.
2. San Marco Monastery
When you're done at the Accademia, head just a few blocks to another amazing Florence art spot, the Museum of San Marco Monastery. San Marco is an extraordinary decorative complex, one of the most unusual things to do in Florence. You can admire art in its original in situ location and understand how contemporary audiences experienced it.
At this Renaissance convent-museum, you travel back in time to a nearly perfectly preserved 600 year old Dominican monastery. It was paid for by Medici family money, designed by the stellar architect Michelozzo, and decorated with delicate frescos by one of the best painters of the Renaissance -- Fra Angelico. The fiery preacher Girolamo Savonarola even lived there, in the monks dormitory cells.
You're likely ready for lunch. This is a good time to explore the San Lorenzo markets. There are two of them, an outside street market and an indoor food court known as the Central Market. I can recommend a rustic gem, Trattoria la Burrasca, on the market's north corner.
3. Santa Maria Novella
After lunch, tour the beautiful Basilica of Santa Maria Novella and the Piazza della Repubblica. Santa Maria Novella was founded in 1279 by a Dominican order. The basilica has a similar design to the Duomo. Polychrome and white marble create a striking front facade.
The interior is a true marvel. It holds one of the most famous paintings in Italy, the Holy Trinity by Early Renaissance artist Masaccio. You'll want to inspect three important highlights -- the Strozzi Chapel, the Filippo Chapel, and the Spanish Chapter House.
4. Basilica of San Lorenzo Complex
Next, head to the monumental complex of the Basilica of San Lorenzo. The complex is a veritable haven of Renaissance art and architecture, a must see for art and history buffs.
The complex is vast, including: the basilica itself, Brunelleschi's Old Sacristy, Michelangelo's New Sacristy, the Medici Chapel, the Medici Crypt, and the Laurentian Library.
Most importantly? It has the largest number of Michelangelo sculptures in Florence, quite a selling point. And a Michelangelo-designed library. If you're on the Michelangelo trail, the the Medici Chapel and the Laurentian Library are must see sites in Florence.
5. Palazzo Vecchio & Piazza della Signoria
In the evening, head to the magnificent Palazzo Vecchio. It's one of the few Florence attractions that's open at night. The Palazzo Vecchio was the seat of government and one of the three palace-residences of the Medici dynasty. It sits in the Piazza della Signoria, which is essentially a free open air sculpture gallery.
It's definitely worth going inside the Palazzo Vecchio, though so many tourists don't. The Palazzo Vecchio is a doughty medieval fortress on the outside and a resplendant Renaissance palace on the inside. You can admire the stunning Michelozzo-designed courtyard, explore the grand Hall of the Five Hundred, admire Michelangelo and Donatello sculptures, and gaze admiringly at beautiful frescos at every turn.
The Tower of Arnolfo can be climbed, and provides fantastic views over Florence and the Duomo. And the lines aren't nearly as long as for Brunelleschi's dome.
Day 8: Explore Siena En Route To Rome
Siena is about an hour from Florence. It's one of the best cities to visit in Tuscany for its rustic medieval beauty, tasty food, and luscious chianti. If you want to bask in medieval times, there's no better place. I guarantee you'll fall in love.
You'll want to spend ample time strolling through the pedestrianized historic center. It's a well-preserved burnt orange dream littered with cute cafes and shops. With literally every cultural activity imaginable, stroll-able medieval Siena really deserves more than a day to soak up its rose-hued charms.
But Siena is compact and can be managed in 24 hours, if you're efficient. I've written a one day itinerary and guide for Siena. It takes you to Siena's must see architectural sites, museums, and piazzas. You'll stroll through the pedestrianized historic center, which is a well-preserved burnt orange dream littered with cute cafes and shops.
Here's my detailed step by step one day itinerary to making the most of one day in Siena.
Siena's most famous site is its Duomo, Siena Cathedral. It's one of Europe's most beautiful churches, especially for lovers of all things Gothic. It's the symbol of Siena, clad all over in Siena's trademark white and dark green marble. Consistent with the Gothic ethos that "more is always better," every inch is decorated with marble, mosaics, sculptures, and frescos.
Don't stay too late in Siena. It's over 2.5 hours to Rome. When you arrive in Rome, drop your car off. You won't need or want it in Rome.
If you have an extra day in this area, considering stopping and overnighting in beautiful Orvieto en route from Siena to Rome. Orvieto is an elegant cathedral hill town only 1.5 hours from Rome.
Day 9: Explore Rome
Founded by the twins Romulus and Remus in 753 B.C., Rome once ruled the entire known world. Ro